DefenAge™ Skincare

Inspired by the recent discovery of the skin’s regeneration process, the scientists at DefenAge™ have identified how to unlock the key to youth with powerful peptides called Age-Repair Defensins™. Paradigm-shifting DefenAge is the FIRST and ONLY 4th generation skin care featuring this stand-alone breakthrough NATURAL mechanism of action. Patent-pending and exclusively available in DefenAge.

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DefenAge® 6-Week Perfection Neck Cream Named NewBeauty Award Winner

The Only Neck Cream with Defensin-Molecules Proven to Deliver Treatment-like Results for Visible Tightening and Firming of the Neck Skin.

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What makes DefenAge™ different?

Scientific research shows the defensin-molecule can reprogram dormant cells in our body to generate visibly newer, healthier, and truly youthful new skin. Scientists at DefenAge implemented this revolutionary discovery in their formulas. Defensins are exclusive to DefenAge, the technology is patent-pending, and may be combined with almost any skin care regimen.

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4 fl oz
Available at both locations

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After two years of development, DefenAge proudly introduces the first-ever defensin-containing lotion. Every woman will want and need this hand and body cream.

Why 10 luxe hand & body cream is different

  • Visibly enhances firmness and cosmetic elasticity.
  • Improves the appearance of crepey skin.
  • Refines the surface skin texture.
  • Provides both instant and long-lasting hydration, including in dry climates. Boosts natural moisture retention. Skin feels firmer and plumper immediately.
  • Relieves the feeling of dryness and itching.
  • Balances the skin’s barrier function.
  • Promotes the skin’s natural hyaluronic acid, laminin, and elastin.
  • Improves visible skin thickness.
  • Reverses signs of skin aging, premature aging, and sun damage.
  • Effective on elbows and knees; visibly revives their smooth texture and revitalizes softness.
  • Smooths and softens the skin on the hands.
  • Keeps skin glowing all over the body.
  • Beneficial in combination with body contouring procedures to improve visible skin firmness and overall skin quality.
  • Recommended in pairing with skin rejuvenation treatments (i.e. peels, IPL, microneedling, and lasers) to amplify results in the reduction of the look of pigmentation, sun damage, crepeness, and mild skin laxity.

Why it’s different

  • Contains defensin-molecules. Encompasses 7-year knowledge and research collected on the clinical performance of defensins.
  • Provides anti-aging benefits on a global scale.
  • Promotes new ‘younger’ skin.
  • Effective on both the hands and body.
  • Fast acting: first results from ‘immediate’ to 1 week, full range of results in 6 weeks.
  • Non-irritating retinol alternative. Delivers retinol-like results.
  • Rich luxurious texture, elegant feel, clean smell of natural ingredients. Fragrance free.
  • Absorbs quickly, not sticky or tacky, does not leave a greasy feeling.
  • Four-pillar formulation strategy:
    • Global anti-aging (defensin-molecules)
    • Natural moisturization & comprehensive barrier repair (Ophiopogon japonicus root extract, Sinorhizobium meliloti ferment)
    • Soothing & calming via anti-inflammation (sea whip, panthenol)
    • DefenAge’s hero blend of ingredients proven to be well-paired with defensins (incl. niacinamide, squalane)
  • Advanced clean beauty standards, No PEGs or animal- or human-derived ingredients.
  • Developed in response to demand by the medical community, aesthetic service providers, and customers.

24/7 Barrier Balance Cream

Age-Repair Defensins™ put the focus on youthful-looking skin where it begins. These biologically-advanced peptides are infused into this ultra-hydrating lightweight cream and unified with energizing to visibly correct surface signs of aging cell-by-cell. Patent-pending technology.

8-IN-1 Bioserum

1 fl. oz. (30 ml)

This remarkably smart formula seems to understand your skin’s needs better than your own DNA. Designed to activate, orchestrate and energize, this biologically-advanced concentrate is infused with the highest daily percentage of Age-Repair Defensins™. Results are equal to 8 separate serums. Patent-pending technology.

2-Minute Reveal Masque

1.5 fl. oz. (45 ml)

See amazing skin-brightening in minutes with this Triple Enzyme resurfacing masque. A blend of ultrafine Sugar Crystals suspended in a gently warming creamy masque, it quickly uncovers the healthy skin beneath surface debris. When used once or twice a week, it helps the products that follow work on the upper skin layers more effectively. Adding water melts the Crystals as you reveal new skin, and an instantly refreshed, younger-looking complexion.

Free from microbeads and fragrance.

Clinical Power Trio

DefenAge’s core 3-piece regiment

2-Minute Reveal Masque | Net Wt. 2.5 oz.
24/7 Barrier Balance Cream | 1.5 fl. oz.

8-in-1 BioSerum | 1.0 fl. oz.
Visible correction of up to 16 signs of aging just in 6 weeks!*

Revives Youthful Firmness • Brightens Age Spots • Defines Contours • Smoothes Lines • Diminishes Wrinkles • Unclogs & Minimizes Pores • Comforts Sensitivity • Evens Skin Tone • Corrects Surface Imperfections • Revives Clarity • Replenishes Moisture • Repairs Dryness • Refines Texture • Renews Softness • Revitalizes Dullness • Calms Redness

Fly Kit

2-Minute Reveal Masque | Net Wt. 0.75 oz.
24/7 Barrier Repair Cream | 0.5 fl. oz.
8-in-1 BioSerum | 0.33 fl. oz.
Travel sizes in DefenAge’s cosmetic bag.
TSA Friendly.
Preview your long-term results while enjoying initial savings.

Click here for DefenAge Products

Anti-Aging with DefenAge

Before & After Results Using DefenAge™

DefenAge™ does not contain the following:

  • Animal- or human-derived ingredients
  • Parabens or formaldehyde-releasing preservatives
  • Sulfates
  • Irritating acids or abrasives
  • Strong emulsifiers
  • Chemical sunscreens
  • Mineral oil, petrolatum or paraffin
  • Colorants
  • Phthalates
  • B PA
  • Propylene glycol
  • Triethanolamine
  • Gluten ingredients (no wheat, oats, barley)

Dr. Bucay was featured on the Mtn. Grove News Journal for her JDD Defenage Investigation

Regenerative medicine in action: Age-Repair Defensins turn the table on facial aging

Dr. Bucay is a DefenAge Diamond Partner!

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Schedule A Consultation



01. Get to know Dr. Bucay, Dr. Bhandari and Dr. Noorily.

02. Help her understand you and your goals.

03. Learn about our services and specialties.

“Very comfortable environment, all staff very were very professional, and Dr. Bucay was a delight. She is an artist with the skills and compassion that focus specifically on the clients needs. Dr. Bucay is amazing.”

–Jorie K.


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Se habla espanol!

Talia Noorily MD

A Message from Dr. Bucay: Champions for Change Gala

This year I am honored to join the committee for the Champions for Change Gala, taking place on May 10, 2023 at Ziegfield Ballroom in NYC.

Champions for Change Gala
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